Langendorff's isolated perfused rat heart technique: a review
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چکیده
منابع مشابه
The isolated air perfused rat heart.
A simple method has been developed for continuous monitoring of metabolic activity of an isolated, perfused rat heart by O2/CO2 respirometer. Since respirometer provides vital data on oxygen consumption and carbon dioxide production of a preserved organ on a continuous basis over a long period of time, it will be possible to use this method to monitor viability of not only isolated heart but al...
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Introduction: Beat-to-beat variation in heart rate shows a complex dynamics, and this complexity is changed during systemic inflammatory response syndrome (e.g. sepsis). It is not known whether or not cardiac pacemaker dynamical rhythm is affected by sepsis. The aim of this study was to investigate heart rate dynamics of isolated heart as well as expression of pacemaker channels (HCN) in a r...
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The isolated perfused heart system, as originated by Oscar Langendorff more than a century ago, has become a predominant technique in pharmacological and physiological research. The technique allows the examination of cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects without the complications of an intact animal model. From its simple begin...
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its lower bulk density and its greater surfacelg ratio, as reflected by an ability to adsorb more protein from serum. The pores are much larger than those present in gel-filtration particles and they cannot therefore discriminate between proteins on the basis of size. Preliminary studies suggest that the inclusion of Factor X by these pores renders it comparatively more stable than Factor X bou...
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ژورنال
عنوان ژورنال: International Journal of Basic and Clinical Pharmacology
سال: 2015
ISSN: 2319-2003
DOI: 10.18203/2319-2003.ijbcp20151381